Virtual Opportunistic Reaction Perimetry (VORP) — The Holy Grail of Vision Testing to Prevent Irreversible Vision Loss and Blindness Worldwide

Votes: 9
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Medical

Vision loss is a global emergency. The World Health Organization estimates that 2.2 billion people live with vision impairment - at least 1 billion preventable or still unaddressed - costing the world about US$411 billion in lost productivity yearly. The leading blinding diseases keep climbing: by 2040, glaucoma will affect 112 million people and age-related macular degeneration 288 million; diabetic retinopathy will hit 161 million by 2045; and by 2050, blindness will rise to 61 million and moderate-to-severe vision impairment to 474 million. Most of this blindness is irreversible if caught late but preventable if caught early - and early detection depends on visual field testing (perimetry).

Yet the gold standard of care, standard automated perimetry (SAP, e.g., the Humphrey Field Analyzer), rests on two fragile requirements: the patient must hold central fixation throughout the exam, pressing a button at every perceived stimulus. Fixation loss corrupts results - most cruelly in macular disease, where the very defect being measured destroys fixation - while button responses are subjective and fatiguing. SAP also requires costly, heavy, non-portable instruments in a darkened room.

VORP overturns this paradigm, requiring neither fixation nor any active response - the long-sought "holy grail" of perimetry. Through a virtual-reality headset with built-in high-frequency eye/gaze tracking, VORP asks the subject only to look toward any stimulus noticed. Knowing the gaze position in real time, the software "opportunistically" places each new stimulus at an untested eccentricity relative to the current gaze - a self-adapting, Game-of-Battleship-like strategy. The eye's movement toward - or failure to reach - each stimulus reveals what subjects can and cannot see, mapping their visual field and its scotomas (visual field defects). By exploiting these gaze shifts, VORP tests a visual field up to four times the headset's native display, while capturing medically revealing quantities, such as eccentricity, gaze direction, trajectory, velocity, reaction speed, and focusing accuracy - data unattainable with SAP.

This objective, reaction-based design unlocks uses far beyond disease screening: flagging traumatic brain injury and concussion from battlefield blasts and full-contact sports (football, boxing, kickboxing, martial arts); monitoring the visual-field changes of Spaceflight-Associated Neuro-ocular Syndrome (SANS) and radiation injury in astronauts on long-duration missions in low-Earth orbit, on the Moon, and toward Mars; and, needing no verbal feedback, testing animals in pharmaceutical trials, cutting animal numbers and testing time.

VORP's striking advantage is self-sufficiency: it needs only a VR headset with accurate eye tracking and an embedded computer - a standalone unit. Because the headset occludes ambient light, no clinic or controlled lighting is required: VORP performs equally in bright desert daylight or arctic darkness - deployable anywhere: in space, remote and underserved regions, battlefields, sports arenas, and the developing world where care is scarce.

Production is cheap: VORP is software on commodity, mass-produced consumer VR hardware - no custom instruments - for a fraction of the $20,000-$30,000 cost of conventional perimeters. VORP is patented (U.S. 11,684,256B2); a proof-of-concept has been demonstrated using C/C++ and the Unity game engine. Easy to manufacture and scale, VORP can transform the quality and equity of eye health for hundreds of millions worldwide.

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  • About the Entrant

  • Name:
    Wolfgang Fink
  • Type of entry:
    team
    Team members:
    • Wolfgang Fink
    • John Cerwin
    • Christopher Adams
  • Profession:
    Scientist
  • Software used for this entry:
    C/C++ and Unity Game Engine