Hemorrhoids affect an estimated 10 % of adults worldwide, yet most topical treatments cause burning, stinging and require frequent re-application. We have developed a multilayer transdermal patch that delivers active compounds away from the inflamed tissue, minimizing local irritation and improving patient compliance.

How it works:

• Backing layer: A biocompatible polymer prevents direct contact with the haemorrhoidal plexus.
• Rate-controlling matrix: Incorporates the active pharmaceutical ingredient (API) and excipients into a polymer network that releases the drug in a controlled manner over 12–24 hours.
• Adhesive layer: Ensures gentle, secure adhesion to perianal skin.
• Release liner: Protects the patch until application.

Upon application to intact perianal skin, the patch’s permeation enhancers facilitate steady diffusion of the API through the epidermis and into the subcutaneous vascular network supplying the haemorrhoidal tissue. This “remote delivery” bypasses the need for alcohol-based sprays or creams that aggravate inflamed skin.

Novelty & Advantages:

• Indirect targeting of sensitive tissue—no burning or stinging.
• Sustained release reduces dosing frequency to once daily.
• Discreet, low-profile design increases acceptance in social and professional settings.
• First-of-its-kind patch specifically formulated for haemorrhoids.

Manufacturing & Feasibility:

All components employ well-known pharmaceutical polymers and adhesives. The patch can be produced on existing roll-to-roll coating lines, with standard lamination and die-cutting processes—minimizing capital investment. In vitro Franz-cell studies show > 70 % of API delivered into target-tissue analogues within 8 hours; ex vivo porcine skin assays confirm no irritation.

Applications & Market:

Ideal for mild-to-moderate hemorrhoid sufferers seeking non-invasive relief. Global topical hemorrhoid treatments market is projected to exceed USD 1 billion by 2027. This patch could displace sprays and ointments in both prescription and OTC segments.