Life Shot: On-site Tissue Repair Solution

Votes: 8
Views: 394
Medical
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The occurrence of wounds or deep injuries in patients located in very distant places, places in conflict or even, in outer space, where the transportation of the patient can be very complicated or it can take days to carry the patient to an attention place, generates risk for lives of people located in these places or circumstances.

In this context, it is necessary to stop the bleeding, protect the wound or injurie and provide a way for the beginning of the tissue repair from the moment the treatment is started. This implies that, in a device, it is necessary to include a solution for hemostasis, providing support at the cellular level for tissue growth and initiation of repair through the insertion of substances that provide growth factors, procoagulants and others facilitators of tissue development.

LIFE SHOT was conceived as an alternative that includes the technology of biomaterials, tissue repair, regeneration stimulants and applied engineering to save people's lives through a treatment that is applied in situ, reducing the risk of complications and generating greater possibilities of survival before serious injuries, in places with limitations for access to health care centers.

LIFE SHOT consists of a receptacle manufactured from a membrane based on protein obtained and purified from the silk cocoon (bombyx morix) which is inserted into the wound through an extensible insertion device, which applies the receptacle. In a second step, the receptacle is filled automatically and under pressure so that the receptacle adapts and fills the wound cavity, in order to generate hemostasis by direct pressure. The main characteristic of the receptacle, is that being a bioactive and bio-integrable material, it does not need to be removed from the wound, without to generate the need for subsequent interventions to remove it. Once hemostasis is achieved, the receptacle begins to interact with the tissue and facilitates the initiation of the repair.

The content with which the receptacle is filled, is composed of a gel manufactured from extracellular matrix, collagen type 1, 3, 4, 5, 6, glucosamine glycans, adhesion molecules and growth factors, including TGF-β and FGF-β and vascular endothelial growth factor. This content continues the repair phase that initiates the receptacle and enhances the process of tissue regeneration.

Description of the Process: the applicator is a device composed of a tubular telescopic tip, which is responsible for applying the receptacle, which externally covers the telescopic tip. When the telescopic tip is retracted, the system seals the end of the receptacle so that it can be loaded with the bioactive content. The telescopic tip is inserted into the wound, after locating the tip to the desired depth, the bioactive gel is started to pump in order to generate homeostasis. Once the desired pressure has been reached, the telescopic tip is retracted and the receptacle end sealed. The receptacle is designed so that after 72 hours, when no signs of infection are detected, it is opened through an ultrasound pulse, releasing the bioactive material.

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  • ABOUT THE ENTRANT

  • Name:
    Victor Manuel Castano
  • Type of entry:
    team
    Team members:
    Victor Manuel Castano, Enrique Isaza, Duverney Gaviria
  • Profession:
    Orthopaedic Surgeon
  • Victor Manuel is inspired by:
    I believe that biotechnology can help save thousands of lifes. My and my team motivation and inspiration, is the use of biotechnology and engineering to save lives, give more life quality to the people and make more sustainable the industry
  • Patent status:
    none