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NETrolyze, a novel immunotherapy for triple-negative breast cancer (TNBC), was named the $25,000 grand prize winner at a live finalist round held November 15 in New York. The first-in-class therapeutic injectable gel prevents the spread of TNBC, one of the most aggressive cancer types, enabling patients to avoid toxic chemotherapy and expensive treatments – potentially transforming their lives. Click here for the full list of 2024 winners. Also see the Top 100 highest scoring entries.

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Special Report spotlights the eight top entries in 2023 as well as past winners whose ideas are now in the market, making a difference in the world.

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A ‘Create the Future’ Winner Featured on ‘Here’s an Idea’

Spinal cord injury affects 17,000 Americans and 700,000 people worldwide each year. A research team at NeuroPair, Inc. won the Grand Prize in the 2023 Create the Future Design Contest for a revolutionary approach to spinal cord repair. In this Here’s an Idea podcast episode, Dr. Johannes Dapprich, NeuroPair’s CEO and founder, discusses their groundbreaking approach that addresses a critical need in the medical field, offering a fast and minimally invasive solution to a long-standing problem.

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3D Endoscope Using Controlled Aberrations

Votes: 0
Views: 8597
Medical

Millions of endoscopy surgeries are performed each year in the US, with even more performed internationally. Endoscopy has advanced rapidly in the last twenty years. However, little progress has been made towards the development of a 3D endoscope system, even decades after they have been proposed in scientific literature. We postulate this is due to the inherent design tradeoffs required by stereoscopic 3D system, the most common 3D imaging modality. Specifically, stereoscopic endoscopes fail to deliver high quality images, lack quantitative depth information about the target, and have difficult delivering the same depth sensitivity as the human eye.

We solve this problem by implementing an entirely new depth sensing modality we call depth measurements through controlled aberrations. This new 3D endoscope device is designed for integration in all endoscope types, even extremely slim endoscopes (stem that can be channeled through a standard illumination path of an endoscope. The production cost of the device would be similar to that of other endoscopy hardware due to the minimal modification to the system. This technique is ideally suited for spatially constrained applications such as endoscopy because the 3-D information is not gathered via triangulation. In fact, this technique can have coincident imaging and illumation optical paths.

Numerous studies have shown that providing surgeons with depth information in endoscopic and laparoscopic surgeries reduces training time and surgeon error. Our device delivers this badly needed depth information without reducing the quality of the final images. This device would also be extremely useful in surgeries that require significant precision and spatial knowledge by the surgeon. Examples of possible surgeries include neurosurgery and in-utero fetal surgery. By delivering 3D information to the surgeons we deliver increased performance, safety, and reduced costs.

Our new 3D endoscope circumvents many of the problems that current solutions offer by using an entirely new method of measuring depth using only an aberrated illumination pattern and standard imaging endoscope. This technology has the potential to revolutionize current endoscopy practices, and bring 3D endoscopy fully into the medical community

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  • ABOUT THE ENTRANT

  • Name:
    Gabriel Birch
  • Type of entry:
    team
    Team members:
  • Profession:
    Student
  • Number of times previously entering contest:
    never
  • Gabriel's favorite design and analysis tools:
    Matlab for image processing, Zemax non-sequential ray tracing for real image simulations. Together you can close the loop and design fully simulated optical designs and image processing algorithms.
  • Gabriel's hobbies and activities:
    Exploring new foods, piano and cello
  • Gabriel is inspired by:
    Optical engineering exists in an interesting place within the realm of science and engineering. A multidisciplinary approach is absolutely necessary when approaching most optical problems. Mechanical design, physics, ancient geometrical designs, quantum mechanics, material science, and chemistry all combine into challenging, fantastic problems to be solved. I find inspiration in unique solutions outside my own discipline. Listening and discussing current research often leads to many new ideas.
  • Software used for this entry:
    Zemax, Matlab
  • Patent status:
    pending